iloperidone boosts amounts of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch. Iloperidone is a time-dependent CYP3A inhibitor and will cause greater plasma amounts of drugs predominantly eradicated by CYP3A4.cannabidiol will increase the stage or influence of diazepam by affecting hepatic enzyme CYP2C19 metabol